Wednesday, July 5, 2017

Research Study Design 1 ~ Topic Selection for a Study on Cannabis & MDMA



                                     Topic Selection
An ethically appropriate plan for a psychological research study has been
designed by this researcher. The research problem and research question, research proposal, reasons to perform study, rational choice theory, and identifying literature will be presented in this article. The research problem and research question will be discussed next.

Research Problem and Research Question

In light of a review of research studies it seems ethically logical to propose a deeper study into alternative methods of treating ADHD and depression. Based on tentative research this researcher wonders why there are not more studies based on alternative medicines and how can doctors ethically prescribe accepted treatments that have been shown to cause adverse reactions? The following terms are used in this proposal: MPH is methylphenidate (better known as Ritalin®), MDMA is methylenedioxymethamphetamine (better known as ecstasy), ADHD is attention deficit
hyperactivity disorder, and Δ9-THC is Δ9-Tetrahydrocannabinol. Next, the research proposal will be discussed.


Research Proposal

It seems appropriate to run a multiple tiered study to look into this research question. Level 1 of the study would involve a control group of young, consenting adults who are depressed receiving psychotropes and an experimental group of the same who stop psychotropes and try MDMA for depression. Level 2 of the study is the same principle; however, it would involve subjects with ADHD, MPH, and cannabis oil. Coded questionnaires would be used at beginning, intervals, and end of the study to be coded into a quantitative study. The study would have a qualitative tier as well in that a questionnaire for prescribing doctors will be analyzed. Compelling reasons to perform this study will be presented next.
 

Reasons to Perform Study

The reasons to perform this study are varied. Concern is raised for the long-term safety of an extensive amount of children and adolescents who have been prescribed the
psychostimulant MHP for ADHD (Marco, et.al., 2011).
“Adolescent exposure to MPH seems to provoke persistent
neurobehavioral consequences: long-term modulation of self-control abilities, decreased sensitivity to natural and drug reward, enhanced stress-induced emotionality, together with an enhanced cortical control over sub-cortical dopamine systems and an enduring up-regulation of Htr7 gene expression within the nucleus accumbens”(Marco, et.al., 2011, para.1).  There is a large amount of evidence that suggests that marijuana can successfully treat ADHD without as many adverse side effects (Waking Times, 2013). Chan, et.al. (1996) concluded that “there was no evidence that Δ9-THC was carcinogenic in rats or mice” (para.1). Although Handland, et.al. (2015) suggest that cannabis oil should not be tested, other studies claim that the cannabinoid system is the body seems to agree with cannabis oil when compared to MPH (Waking Times, 2013). Next, additional reasons will be discussed.

Psychiatric drugs that are prescribed for depression can cause massive changes in the way the brain functions and they have been known to cause severely debilitating and
minutely possible fatal effects (Medical Whistleblower Advocacy Network, n.d.). Bouso, et.al. (2008) found MDMA was physiologically and psychologically safe for all subjects
in their research study that was stopped for “political reasons”. Other researchers are looking into MDMA and lessening its reportedly adverse effects by testing it in clinical
trials (Brice, 2012). Since an age-of-information is sweeping the world with the web it would be beneficial to be on the cutting edge of research that is intended to help customers in lieu of medicating them with possibly dangerous psychotropes when the public realizes what research really reveals and the manner in which big pharma manipulates the health care industry. The public is waking up. A psychological theory that relates to this research proposal will be presented next.
 

Rational Choice Theory

The rational choice theory seems to be a logical assumption when one attempts to speculate the high rates of prescribing seemingly dangerous drugs. The documentary, Making a Killing, describes the system of rewards used by pharmaceutical companies to get doctors to prescribe their products and the placement of FDA members to get unduly
tested drugs to the market (Of Interest, 2012). The rational choice theory states that individuals are motivated by goals or wants so that “the relationship between preferences and constraints can be seen in the purely technical terms of the relationship of a means to an end” (Scott, 2000. p.3). In other words, individuals make choices that help them reach
their goals and are “motivated by the pursuit of a 'profitable' balance of rewards over costs” (Scott, 2000, p.5). Hopes are that the questionnaire will reveal more compassionate reasons for the extensive prescriptions of seemingly dangerous drugs.  Next, a strategy for identifying literature related to the research proposal will be revealed.

Identifying Literature

Former studies provide ample literature to provide evidence that this study design is valid.   Berman, et.al. (2010), Chan, et. al. (1996), and Marco, et.al. (2011) plus other located studies will be used to back this research. Actual studies are listed in Waking Times (2013) and Medical Whistleblower Advocacy Network (n.d.) that will be analyzed since neither google scholar nor the school library seems to list them.
The research problem and research question, research proposal, reasons to perform study, rational choice theory, and identifying literature have been presented and briefly discussed in this article. The research author wishes to make another plea for this study to continue as the public deserves the best treatment with the least possible side effects and it is believed that said public would appreciate a company that attempts to reform the medical industry that seems to serve big pharma more than the public.
 

This is a very well developed proposal and you did a good job laying out the research questions and providing some background to the issue! Keep going with this great start! Please begin to review the unit 4 introduction paper (to the proposal) instructions. More details and a tip sheet to help will be provided to the class shortly. If you have any questions, let me know, Prof M 100%





                                           References
 
Berman, S. M., Kuczenski, R., Mccracken, J. T., & London, E. D. (2010). Potential adverse
effects of amphetamine treatment on brain and behavior: A review. Molecular Psychiatry,
15(11), 1121. doi:http://dx.doi.org.library.capella.edu/10.1038/mp.2010.39
http://search.proquest.com.library.capella.edu/.../759635...
 
Bouso, J. C., B.Sc, Doblin, R., PhD., Farré, Magí, MD, PhD, Alcázar, M. Á., PhD, & Gómez-
Jarabo, G., PhD. (2008). MDMA-assisted psychotherapy using low doses in a small
sample of women with chronic posttraumatic stress disorderdagger]. Journal of
Psychoactive Drugs, 40(3), 225-36. Retrieved from
http://search.proquest.com.library.capella.edu/.../207973...
 
Brice, Makini. (17 Sept, 2012). Could MDMA Be the Cure for PTSD and Depression? Medical
Daily. Retrieved from http://www.medicaldaily.com/could-mdma-be-cure-ptsd-and...
 
Chan, P.C., Sills R.C., Braun A.G., J.K. Haseman J.K., J.R.. and Bucher J.R. (March, 1996).
Toxicity and Carcinogenicity of Δ9-Tetrahydrocannabinol in Fischer Rats and B6C3F1
Mice. Toxicological Sciences. 30 (1): 109-117. doi: 10.1093/toxsci/30.1.109
http://toxsci.oxfordjournals.org/content/30/1/109.short
 
Hadland,Scott E. MD, MPH; Knight, John R. MD; and Harris, Sion K. PhD. (2015). Medical
Marijuana: Review of the Science and Implications for Developmental Behavioral
Pediatric Practice. J Dev Behav Pediatr. 2015 Feb-Mar; 36(2): 115–123.
doi: 10.1097/DBP.0000000000000129. Retrieved from
http://www.ncbi.nlm.nih.gov.library.capella.edu/.../PMC4.../ 
Marco, Eva M; Adriani, Walter; Ruocco, Lucia A; Canese, Rossella; Sadile, Adolfo G; and
Laviola, Giovanni. (Aug, 2011). Neurobehavioral adaptations to methylphenidate: The
issue of early adolescent exposure. Neuroscience & Biobehavioral Reviews. Volume 35,
Issue 8, Pages 1722–1739. doi:10.1016/j.neubiorev.2011.02.011. Retrieved from
http://www.sciencedirect.com.library.capella.edu/.../S014...
 
Medical Whistleblower Advocacy Network. (n.d.). Psychiatric Drug Side Effects. Medical
Whistleblower Advocacy. Human Rights Defenders. Retrieve from
http://medicalwhistleblowernetwork.jigsy.com/psychiatric-dr
 
Of Interest. (23 Dec, 2012). Making a Killing: The Untold Story of Psychotropic Drugging – Full
Movie (Documentary). Of Interest. Retrieved from
https://www.youtube.com/watch?v=rk-ryvdWPgw
 
Scott, John. (2000). Rational Choice Theory. Understanding Contemporary Society: Theories of
The Present. Sage Publications. Pages 1 -15. Retrieved from
http://www.soc.iastate.edu/sapp/soc401rationalchoice.pdf
 
Waking Times. (11 April,2013). Can Medical Cannabis Stop The ADHD Epidemic? Waking
Times. Retrieved from http://www.wakingtimes.com/.../can-medical-cannabis-stop.../

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